UPMC’s Dr. Aatur Singhi Speaks on Early Diagnosis of Pancreatic Cysts

Watch an interview with the Director of UPMC Clinical Test Development Laboratory, Dr. Aatur Singhi, on Pittsburgh Today Live, as they discuss the importance of early testing and detection when fighting Pancreatic Cancer.

Genomic Test IDs Pancreatic Cysts Likely to Progress to Cancer Better Than Standard Guidelines

NEW YORK – In a prospective study of more than 1,800 patients at 31 clinical centers in the US, the PancreaSeq test developed at the University of Pittsburgh surpassed currently used guidelines for correctly classifying potentially cancerous pancreatic cysts.

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

Singhi AD, McGrath K, Brand RE, Khalid A, Zeh HJ, et al. Gut. 2018 Dec;67(12):2131-2141.

Integrating Molecular Analysis into the Pathologic Evaluation of Pancreatic Cysts

Bell PD, Singhi AD. Surg Pathol Clin. 2022 Sep;15(3):455-468.

Early detection of pancreatic cancer using DNA-based molecular approaches

Singhi AD, Wood LD. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):457-468.

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

Singhi AD, Wood LD, Parks E, Torbenson MS, Felsenstein, et al. Gastroenterology. 2020 Feb;158(3):573-582.e2.

American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data

Singhi AD, Zeh HJ, Brand RE, Nikiforova MN, Chennat JS, et al. Gastrointest Endosc. 2016 Jun;83(6):1107-1117.e2.

Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts

Singhi AD, Nikiforova MN, Fasanella KE, McGrath KM, Pai RK, et al Clin Cancer Res. 2014 Aug 15;20(16):4381-9.

Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts

Nikiforova MN, Khalid A, Fasanella KE, McGrath KM, Brand RE, et al. Mod Pathol. 2013 Nov;26(11):1478-87.

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