Pitt-Developed Genetic Test for Pancreatic Cancer Outperforms Current Guidelines

PITTSBURGH —A molecular test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, according to a large, multi-center study led by University of Pittsburgh School of Medicine and UPMC researchers. 

A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising from Pancreatic Cysts

Nikiforova MN, Wald AI, Spagnolo DM, Melan MA, Grupillo M, et al. Ann Surg. 2023 May 22.

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, et al. Gastroenterology. 2023 Jan;164(1):117-133.e7.

The World Health Organization Reporting System for Pancreaticobiliary Cytopathology

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, et al. Acta Cytol. 2023;67(3):304-320.

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer CG, Beleva Guthrie V, Braxton AM, Zheng L, Wang P, et al. Gastroenterology. 201 Oct;157(4):1123-1137.e22.

A multimodality test to guide the management of patients with a pancreatic cyst

Springer S, Masica DL, Dal Molin M, Douville C, Thoburn CJ, et al. Sci Transl Med. 2019 Jul 17;11(501):eaav4772.

A combination of molecular markers and clinical features improve the classification of pancreatic cysts

Springer S, Wang Y, Dal Molin M, Masica DL, Jiao Y, et al. Gastroenterology. 2015 Nov;149(6):1501-10.

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

Amato E, Molin MD, Mafficini A, Yu J, Malleo G, et al. J Pathol. 2014 Jul;233(3):217-27.

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development

Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, et al. Sci Transl Med. 2011 Jul 20;3(92):92ra66.

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