A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising from Pancreatic Cysts

Nikiforova MN, Wald AI, Spagnolo DM, Melan MA, Grupillo M, et al. Ann Surg. 2023 May 22.

Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts

Paniccia A, Polanco PM, Boone BA, Wald AI, McGrath K, et al. Gastroenterology. 2023 Jan;164(1):117-133.e7.

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

Singhi AD, McGrath K, Brand RE, Khalid A, Zeh HJ, et al. Gut. 2018 Dec;67(12):2131-2141.

Integrating Molecular Analysis into the Pathologic Evaluation of Pancreatic Cysts

Bell PD, Singhi AD. Surg Pathol Clin. 2022 Sep;15(3):455-468.

The World Health Organization Reporting System for Pancreaticobiliary Cytopathology

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, et al. Acta Cytol. 2023;67(3):304-320.

Early detection of pancreatic cancer using DNA-based molecular approaches

Singhi AD, Wood LD. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):457-468.

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

Singhi AD, Wood LD, Parks E, Torbenson MS, Felsenstein, et al. Gastroenterology. 2020 Feb;158(3):573-582.e2.

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer CG, Beleva Guthrie V, Braxton AM, Zheng L, Wang P, et al. Gastroenterology. 201 Oct;157(4):1123-1137.e22.

A multimodality test to guide the management of patients with a pancreatic cyst

Springer S, Masica DL, Dal Molin M, Douville C, Thoburn CJ, et al. Sci Transl Med. 2019 Jul 17;11(501):eaav4772.

American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data

Singhi AD, Zeh HJ, Brand RE, Nikiforova MN, Chennat JS, et al. Gastrointest Endosc. 2016 Jun;83(6):1107-1117.e2.

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